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http://dspace.zsmu.edu.ua/handle/123456789/23255
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Название: | Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility |
Авторы: | Koval, H. D. Chopyak, V. V. Kamyshnyi, O. М. Kurpisz, M. K. Камишний, Олександр Михайлович |
Ключевые слова: | endometriosis infertility T-helper cells T-bet GATA3 Foxp3 |
Дата публикации: | 2018 |
Библиографическое описание: | Transcription regulatory factor expression in T-helper cell differentiation pathway in eutopic endometrial tissue samples of women with endometriosis associated with infertility / H. D. Koval, V. V. Chopyak, O. М. Kamyshnyi. M. K. Kurpisz // Central European Journal of Immunology. - 2018. - Vol. 43, N 1. - P. 90–96. - https://doi.org/10.5114/ceji.2018.74878. |
Аннотация: | Endometriosis is a disease of epidemiological gravity of unknown primary reason. A complex of constitutional
factors including the immune system has been considered as its background.
The aim of the study was to identify Th1 and Th2 cells as well as the T-regulatory subset in the endometrium
of women with endometriosis associated with infertility upon transcription factors expression.
Expression of T-bet, GATA 3, and Foxp3 genes was examined using a method of polymerase chain reaction
(PCR) in the eutopic endometrial samples of 20 women with endometriosis associated with infertility
and 20 women with infertility of tubal origin. An increase in mRNA expression for T-bet and GATA3
with prevailing mRNA level for T-bet and a decrease in Foxp3 expression were observed. In conclusion,
the revealed changes in expression of transcription factors may indicate the imbalance between T-helper
cells of the Th1 and Th2 type and elimination of regulatory function of T-cells, which can be one of
the causes of endometriosis predisposing to the development of infertility associated with this disease. |
URI: | http://dspace.zsmu.edu.ua/handle/123456789/23255 |
Располагается в коллекциях: | Наукові праці. (Мікробіологія)
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