Роль статинів у комплексній терапії хворих із фібриляцією передсердь

Abstract

Фібриляція передсердь є одним із видів тахіаритмій, що найбільш часто зустрічаються. Наявні на сьогодні дані наукових досліджень указують на тенденцію збільшення маркерів запалення при фібриляції передсердь. Статини беруть участь у регулюванні різних металопротеїназ, що може відіграти роль у регулюванні структурної перебудови, пов’язаної з фібриляцією передсердь. Atrial fibrillation (AF) is one of the most common arrhythmia leading to disability in clinical practice. Diagnosis and treatment of atrial fibrillation remains a serious problem and that urges doctors and researchers to look for new solutions in the tactics of treating this disease. Despite enormous progress in the understanding of many electrophysiological mechanisms of the arrhythmia formation, now there is no universal method for AF treatment. Successful treatment of AF depends on the disease, which lies in the basis of arrhythmia. Currently available data researches indicate a tendency increasing for inflammation markers in patients with AF. The hypothesis of atrial fibrillation induction by inflammatory stress has become a prerequisite to the study of anti-inflammatory drugs influence on the frequency of AF relapses after cardioversion. Thanks to the discovery of pleiotropic properties of statins researchers began to investigate actively the possibility of expansion of indications for their use. Statins have been used for more than 20 years, and new information about their effects is accumulating. There is information about the effective use of statins’ application in the treatment of patients with arrhythmias, cardiomyopathy, gallstones, cancer, diabetes mellitus. The possibility of the impact of statins on AF has been actively studied in recent years. High-quality studies of statins use in the treatment of patients with AF are rare and most of the evidence have been obtained in observational and retrospectives studies. In randomized studies the effects of statins on AF revealed a positive correlation with the successful cardioversion. The preventive effect of statins in atrial fibrillation is likely to occur due to the improvement of lipid exchange and prevention of atherosclerosis, anti-inflammatory and antioxidant activity.